Luhan Pharmachem Co., Ltd.

Cytarabine, a synthetic pyrimidine nucleoside, is converted intracellularly, primarily by deoxycytidine kinase, to active cytarabine triphosphate.
 Activity occurs primarily as the result of inhibition of DNA polymerase via competition with 
deoxycytidine triphosphate, resulting in the inhibition of DNA synthesis. Incorporation of cytarabine into DNA and RNA may contribute to cytotoxic effects.Cytarabine also has antiviral and immunosuppressive properties.Cytarabine is cell cycle phase-specific for the S-phase; cytarabine may also block progression from the G1-phase to the S-phase.Both concentration and duration of exposure are critical for cytotoxicity.

cas no. 147-94-4