Product name: Palonosetron
CAS number: 135729-61-2
Formula: C19H24N2O
Mol. mass: 296.407 g/mol
Properties:white crystalline powder
Palonosetron (INN, trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV—nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy—and is the only drug of its class approved for this use by the U.S. Food and Drug Administration.As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use.
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