Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Isavuconazonium Sulfate bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Isavuconazonium Sulfate is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Isavuconazonium sulfate?

Isavuconazole (trade name Cresemba) is a triazole antifungal drug. Its prodrug, isavuconazonium sulfate, was granted approval by the U.S. Food and Drug Administration (FDA) on March 6, 2015.

During its Phase III drug trials, Astellas partnered with Basilea Pharmaceutica, the developer of the drug, for rights to co-development and marketing of isavuconazole.

On May 28, 2013, Basilea Pharmaceutica announced it had been granted orphan drug status by the FDA for treatment of aspergillosis. Since then, it has also been granted orphan drug status for the treatment of invasive candidiasis.

Mode of Action

Isavuconazole works by inhibiting lanosterol 14 alpha-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and build up of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi.

Side Effects

Common

• Cardiovascular: peripheral edema
• Endocrine: hypokalemia
• Gastrointestinal: constipation, diarrhea, nausea, vomiting
• Musculoskeletal: backache
• Neurologic: headache
• Respiratory: cough

Rare

• Hepatic: cholestasis, hepatitis, increased liver function tests, liver failure
• Immunologic: hypersensitivity reaction
• Renal: renal failure
• Respiratory: acute respiratory failure
• Other: infusion reaction (IV only)

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.