Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Dinoprost Tromethamine (Prostaglandin F2?) bulk Active Pharmaceutical Ingredients (API) to pharmaceutical industry. Our Dinoprost Tromethamine is produced by cGMP Compliant factory. Welcome to contact us for availability, Drug Master File (DMF) and FDA approval status of our manufacturing facilities.

What is Dinoprost Tromethamine?

Dinoprost Tromethamine (Prostaglandin F2?, PGF2? in prostanoid nomenclature), pharmaceutically termed dinoprost (INN), is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF2? is dependent on the number of receptors on the corpus luteum membrane.

The PGF2? isoform 8-iso-PGF2? was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress

Synthesis

In 2012 a concise and highly stereoselective total synthesis of PGF2? was described. The synthesis requires only seven steps, a huge improvement on the original 17-steps synthesis of Corey and Cheng, and uses 2,5-dimethoxytetrahydrofuran as a starting reagent, with S-proline as an asymmetric catalyst.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.