Luhan Pharmachem Co., Ltd.

Luhan Pharmachem Co., Ltd. supplies Vorapaxar bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Vorapaxar is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Vorapaxar?

Vorapaxar (brand name Zontivity, formerly known as SCH 530348) is a thrombin receptor (protease-activated receptor, PAR-1) antagonist based on the natural product himbacine. Discovered by Schering-Plough and currently being developed by Merck & Co., it is a pharmaceutical treatment for acute coronary syndrome chest pain caused by coronary artery disease.

Mechanism of action

Vorapaxar is a new anti-platelet drug that is part of the PAR-1 antagonist family, a new class of anti-platelet drug. It functions by inhibiting thrombin-related platelet aggregation. This mechanism works by a different pathway than other anti-platelet medications such as aspirin and P2Y12 inhibitors. Unlike many other medication, vorapaxar does not affect ADP-mediated platelet aggregation, coagulation parameters, or bleeding time.

Storage

Vorapaxar can be stored at 20-25°C(68-77°F). It is best to store vorapaxar in original packaging with the bottle tightly closed and to avoid moisture.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.