Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Tenofovir bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Tenofovir is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Tenofovir?

Tenofovir disoproxil, marketed by Gilead Sciences under the trade name Viread (as the fumarate, TDF), belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial viral enzyme in human immunodeficiency virus 1 (HIV-1) and hepatitis B virus infections.

It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system.

Uses

HIV-1 infection: Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. This indication is based on analyses of plasma HIV-1 RNA levels and CD4 cell counts in controlled studies of tenofovir in treatment-naive and treatment-experienced adults.

Tenofovir is indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.

Side Effects

The most common side effects associated with tenofovir include nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence. Tenofovir has also been implicated in causing renal toxicity, particularly at elevated concentrations.

Tenofovir can cause acute renal failure, Fanconi syndrome, proteinuria, or tubular necrosis. These side effects are due to accumulation of the drug in proximal tubules. Tenofovir can interact with didanosine by increasing didanosine’s concentration. It also decreases the concentration of atazanavir sulfate.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.