Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Metoprolol Succinate bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Metoprolol Succinate is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Metoprolol Succinate?

Metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 23.75, 47.5, 95 and 190 mg of metoprolol succinate equivalent to 25, 50, 100 and 200 mg of metoprolol tartrate, USP, respectively.

What is the mechanism of action?

Metoprolol Succinate is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. It has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. Hypertension The mechanism of the antihypertensive effects of beta-blocking agents is not fully known. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity. Angina pectoris Metoprolol blocks the catecholamine-induced increases in heart rate, velocity and extent of myocardial contraction, and in blood pressure, metoprolol reduces the oxygen requirements of the heart at any given level of effort. Heart failure Tthe precise mechanism for the beneficial effects of beta-blockers in heart failure is not known.

How to dose Metoprolol Succinate?

The recommended starting dosage of metoprolol succinate for people with high blood pressure (hypertension) is 25 mg to 100 mg once a day. After a week or more, based on the blood pressure response and/or metoprolol succinate side effects, the metoprolol succinate dosage may be increased or decreased. Your healthcare provider may also add a diuretic (a “water pill”) or another blood pressure medication if your blood pressure is not controlled by metoprolol succinate alone.

The maximum recommended daily dose of metoprolol succinate for this use is 400 mg.

What are the side effects?

• Cardiovascular
• Hepatitis
• Vomiting
• Thrombocytopenia
• Arthralgia
• Anxiety/nervousness
• Hallucinations
• Paresthesia
• Male impotence
• Inreased sweating
• Photosensitivity
• Urticaria
• Taste disturbances

Storage

Store at room temperature (77 degrees F or 25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.