Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Bortezomib bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Bortezomib is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

Why is this medication prescribed?

Bortezomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with at least one other medication. Bortezomib is also used to treat people with mantle cell lymphoma (a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other medication. Bortezomib is in a class of medications called antineoplastic agents. It works by killing cancer cells.

More  information

CAS No.:179324-69-7

How should this medicine be used?

Bortezomib comes as a solution (liquid) to inject into a vein. Bortezomib is given by a doctor or in a medical office or clinic. It is usually given on a rotating schedule that alternates 2 weeks when bortezomib is given twice a week with 10 days when the medication is not given. During the weeks that bortezomib is given, check doses will always be at least 72 hours apart. The rotating schedule may be followed for up to eight cycles. After that, search your doctor may decide to continue your treatment, but you will receive bortezomib less often.

Be sure to tell your doctor how you are feeling during your treatment. Your doctor may stop your treatment for a while or decrease your dose of bortezomib if you experience side effects of the medication.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other uses for this medicine

What special precautions should I follow?

Before using bortezomib,tell your doctor and healthcare provider if you are allergic to bortezomib, mannitol, any other medications, or boron.

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, or nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S., E-Mycin, Erythrocin); fluvoxamine; certain antifungals such as itraconazole (Sporanox) or ketoconazole (Nizoral); medications to treat diabetes or high blood pressure; certain medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as indinavir (Crixivan), nelfinavir (Viracept), or ritonavir (Norvir); certain medications to treat seizures such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin, Phenytek); mibefradil (no longer available in the U.S.); nefazodone; rifabutin (Mycobutin); rifampin (Rifadin, Rifamate, Rimactane, others); troleandomycin (TAO) (no longer available in the U.S.); or verapamil (Calan, Covera, Isoptin, in Tarka, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what herbal products you are taking, especially St. John’s wort.

Tell your doctor if you or anyone in your family has or has ever had heart disease and if you have or have ever had a herpes infection (cold sores, shingles, or genital sores); diabetes; fainting; high cholesterol (fats in the blood); low or high blood pressure; peripheral neuropathy (numbness, pain, tingling, or burning feeling in the feet or hands) or weakness or loss of feeling or reflexes in a part of your body;or kidney or liver disease. Also tell your doctor if you smoke or drink large amounts of alcohol.

Tell your doctor if you are pregnant or plan to become pregnant. Bortezomib may harm the fetus. Use birth control to prevent pregnancy during your treatment with bortezomib.Ask your doctor if you have questions about types of birth control that will work for you. If you become pregnant while using bortezomib, call your doctor immediately.

Do not breast-feed during your treatment with bortezomib. After your treatment has finished, talk to your doctor or about when it is safe to restart breast-feeding.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are using bortezomib.

You should know that bortezomib may make you drowsy, dizzy, or lightheaded, or cause fainting or blurred vision. Do not drive a car or operate machinery or dangerous tools until you know how this medication affects you.

You should know that bortezomib may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common in people who have fainted in the past, people who are dehydrated, and people who are taking medications that lower blood pressure. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

What should I do if I forget a dose?

If you miss an appointment to receive a dose of bortezomib, call your doctor right away.

What are the side effects of Bortezomib?

Bortezomib may cause side effects. Tell your doctor if any of these symptoms, or those in the SPECIAL PRECAUTIONS section, are severe or do not go away:

• general weakness
• nausea
• vomiting
• diarrhea
• stomach pain
• anxiety
• back pain
• bone, joint, or muscle pain
• muscle cramps
• difficulty falling asleep or staying asleep

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• pain, burning, numbness, or tingling in the hands or feet
• changes in the sense of touch
• shortness of breath
• cough
• swelling of the feet, ankles, or lower legs
• hives
• rash
• itching
• difficulty breathing or swallowing
• swelling of the face, throat, tongue, lips, eyes, or hands
• hoarseness
• fever, sore throat, chills, or other signs of infection
• unusual bruising or bleeding
• black and tarry stools
• bloody vomit
• slurred speech or inability to speak or understand speech
• loss of balance or coordination
• loss of memory
• vision changes or loss of vision
• pale skin
• fast heartbeat
• fainting
• headache
• hallucinating (seeing things or hearing voices that do not exist)
• confusion
• restlessness
• thirst
• loss of appetite
• seizures

Bortezomib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?

Overdose

Symptoms of overdose may include the following:

• fainting
• dizziness
• blurred vision
• unusual bruising or bleeding

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to bortezomib.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Disclaimer

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.