Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd.  supplies Ropivacaine HCl bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Ropivacaine HCl is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Ropivacaine HCl?

Ropivacaine HCl is chemically described as S-(-)-1-propyl-2, recipe 6 pipecoloxylidide hydrochloride monohydrate. The drug substance is a white crystalline powder, molecular weight of C17H26N2OCI2O, molecular weight of 328.89.

Indications

Ropivacaine is a local anesthetic given by injection to cause loss of feeling before and during surgery or labor and delivery. It does not cause loss of consciousness.

What is the mechanism of action?

Ropivacaine is a member of the amino amide class of local anesthetics and is supplied as the pure S-(-)-enantiomer. Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone.

Precautions

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your health care professional will make. For ropivacaine, the following should be considered:

Allergies? Tell your health care professional if you have ever had an unusual or allergic reaction to ropivacaine or any other local anesthetic.

Pregnancy? Ropivacaine has not been shown to cause birth defects in humans.

Use of ropivacaine during labor and delivery may rarely cause unwanted effects. This medicine may increase the length of labor by making it more difficult for the mother to bear down (push). It may also cause unwanted effects in the fetus or newborn baby. Before receiving ropivacaine for labor and delivery, you should discuss with your doctor the good the medicine will do as well as the risks of receiving it.

Breast-feeding? It is not known whether ropivacaine passes into breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children? Studies on this medicine have been done only in adolescents and adults, and there is no specific information comparing use of ropivacaine in children with use in other age groups.

Older adults? Many medicines have not been specifically studied in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of ropivacaine in the elderly with use in other age groups. Based on information about similar medicines, it is expected that elderly people will be more sensitive than younger adults to the effects of ropivacaine. This may increase the chance of side effects.

Other medicines? Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your medical doctor or may want to change the dose, or other precautions may be necessary. When you are taking ropivacaine it is especially important that your health care professional knows if you are taking any of the following:

• Amiodarone (e.g., Cordarone) may increase your chance of serious heart side effects

Other medical problems The presence of other medical problems may affect the use of ropivacaine. Make sure you tell your health care professional if you have any other medical problems, especially:

• Heart disease this medicine may make your condition worse
• Kidney disease or
• Liver disease side effects may be more likely in patients with kidney disease or liver disease

What are the side effects of Ropivacaine HCl?

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. While you are in the hospital or in your doctor’s office, your medical doctor or will carefully follow the effects of any medicine you have received. However, some effects may not be noticed until later.

Check with your doctor immediately if any of the following side effects occur:

• Burning or prickling sensation; fever ; itching

Check with your doctor as soon as possible if any of the following side effects occur:

• Back pain; difficulty urinating; headache; pain

Other side effects not listed above may occur in some patients. If you notice any other effects, check with your doctor.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.