Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd.  supplies Icatibant Acetate bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Icatibant Acetate is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Icatibant Acetate?

Icatibant Acetate is a synthetic decapeptide with five non-proteinogenic amino acids. The chemical structure of icatibant acetate is presented below.

Chemical name: D-Arginyl-L-arginyl-L-prolyl-L[(4R)-4-hydroxyprolyl]-glycyl-L[3-(2-thienyl)alanyl]-L-seryl-D-(1, 2,3,4-tetrahydroisoquinolin-3-ylcarbonyl)-L[(3aS,7aS)-octahydroindol-2-ylcarbonyl]-L-arginine, acetate salt.

Icatibant Acetate is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adults 18 years of age and older.

Icatibant Acetate Drug Interaction

Icatibant Acetate is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where Icatibant Acetate may attenuate the antihypertensive effect of ACE inhibitors. Clinical trials to date have excluded subjects taking ACE inhibitors.

Precautions Before Using Icatibant Acetate

Given the potential for airway obstruction during acute laryngeal HAE attacks, patients should be advised to seek medical attention in an appropriate healthcare facility immediately in addition to treatment with icatibant acetate.

Icatibant Acetate side effects

The most commonly reported adverse reactions were injection site reactions, which occurred in almost all patients (97%) in clinical trials. Other common adverse reactions occurring in greater than 1% of patients included pyrexia, transaminase increase, dizziness, and rash.

Icatibant Acetate Overdosage

In a clinical study evaluating a 90 mg dose (30 mg in each of 3 subcutaneous sites), the adverse event profile was similar to that seen with 30 mg administered in a single subcutaneous site.

In another clinical study, a dose of 3.2 mg/kg administered intravenously (approximately 8 times the therapeutic dose for HAE) caused erythema, itching and hypotension in healthy subjects. No therapeutic intervention was necessary.

Icatibant Acetate Storage

• Store between 2 – 25° C (36 – 77° F).
• Do not freeze.
• Store in carton until time of administration.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.