Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Enoxaparin Sodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Enoxaparin Sodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Enoxaparin sodium?

Enoxaparin is a low molecular weight heparin marketed under the trade names Lovenox, Xaparin and Clexane, among others. It is an anticoagulant used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Its use is evolving in acute coronary syndromes (ACS).

What is the mechanism of action?

Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. The anticoagulant effect of enoxaparin can be directly correlated to its ability to inhibit factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation.
Alternatively: Enoxaparin binds to Factor Xa. It does not bind ATIII as the signal peptide is not long enough to bind to ATIII or thrombin.

Side Effects

• Bleeding Note that great care must be taken in use of low molecular weight heparin after major surgery, particularly neurosurgical procedures involving the brain and spine. The risk of inducing or potentiating post-operative bleeding must be balanced against the additional benefit of chemical thromboprophylaxis, over and above the benefits of mechanical means (stockings, boots) of preventing thromboembolism.
• Thrombocytopenia, i.e. can be associated with heparin-induced thrombocytopenia (0.5-5.0% of patients treated for at least five days
• Pain, bruising or irritation; hard, inflamed nodules or an itchy red rash at the injection site
• Symptoms similar to those of hay fever
• Abdominal/chest pain
• Headache
• Hyperkalemia
• Transaminitis

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.