Luhan Pharmachem Co., Ltd.

Luhan pharmachem Co., Ltd. supplies Cloprostenol Sodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Cloprostenol Sodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

Description

Cloprostenol (Cloprostenol Veyx™) is a synthetic prostaglandin analogue, structurally related to prostaglandin F2 (PGF2).

Cloprostenol Veyx Indications

By its ability to shorten the life span of the corpus luteum Cloprostenol Veyx™ can be used to treat certain clinical conditions which delay breeding, to manipulate the estrous cycle to better fit certain management practices, and to induce abortion.

Dosage and Administration

Cloprostenol Veyx™ should be administered by INTRAMUSCULAR INJECTION. Only cattle with functional C.L. can respond to the luteolytic action of Cloprostenol Veyx™. In the cycling animal there are refractory periods of 4 to 5 days before and after ovulation when cattle are not responding to prostaglandin.

• For Therapeutic Indications – 2 mL
• For Controlled Breeding – 2 mL
• For Abortion – 1.5 mL (2 mL for animals over 455 kg)

Warnings

Treated cattle must not be slaughtered for use in food for at least 48 hours after the latest treatment with this drug. No withholding time is required for milk when used according to the label. This product should be handled carefully to avoid accidental self-injection or contact with the skin or mucous membranes of the user. Prostaglandins of the F2? type may readily be absorbed through the skin and may cause bronchospasms and/or miscarriage. Pregnant women, women in childbearing age, asthmatics and people with other respiratory tract diseases should exercise extreme caution when handling this product such as wearing waterproof gloves.

Accidental spillage on the skin should be washed off immediately with water. In case of accidental self-injection, seek medical advice and show the package insert to the doctor. Should respiratory distress result from accidental inhalation or injection, the inhalation of a rapidly acting bronchodilator is indicated.
Keep out of reach of children.

Adverse Reactions

As with other products in this class, when used for induction of parturition, the incidence of retained placenta may be increased depending on the time of treatment.

A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.

Very rarely, anaphylactic reactions have occurred after administration of the product.
Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.

ACTION:

Cloprostenol Veyx™ causes functional and morphological regression of the corpus luteum in cattle. This effect on the life span of the C.L. usually results in estrus two to five days after treatment, followed by ovulation with normal fertility. Cloprostenol Veyx™ alone will not increase fertility.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.